Thiotepa: (thigh-oh-TEE-pah) is a drug that is used to treat bladder cancer. It is a clear liquid that is given through a small tube into your bladder.

Do not drink liquids for 2 hours before your treatment so your bladder will be empty.

Your provider inserts a small rubber tube (catheter) into your bladder and drains out any urine. The thiotepa is given into your bladder by attaching the medication container to the catheter. The amount given is 30-60mls (approximately 2-3 ounces). The catheter is then removed.

You will be asked to hold to the Thiotepa in your bladder for 2 hours after each treatment. At home, spend 1 of the 2 hours lying in bed. Lay on your back for 15 minutes, then on your side for 15 minutes, then on your stomach for 15 minutes, then on your other side for 15 minutes. Or you can stay active for the 2 hours for example by walking. This makes sue that the Thiotepa completely covers the inside of your bladder.

Drink lots of liquids for at least 6 hours after you first empty your bladder. Empty your bladder frequently. This helps prevent bladder problems.

Sit down when you pass urine (for at least 8 hours after your treatment). Flush the toilet twice. Wash your hands and genitals well with soap and warm water. Wash clothes, bedding and toilet articles which have touched your urine in hot soapy water.

Some other drugs may interact with Thiotepa. Tell your doctor if you are taking any other drugs as your dose may need to be changed.

The drinking of alcohol (in small amounts) will not affect the safety or usefulness of thiopeta.

Thiotepa may cause sterility in men and menopause in women which may be permanent. If you plan to have children, discuss this with your doctor before being treated with Thiotepa.

Tell your doctors or dentists that you are being treated with Thiotepa before you receive any treatment from them.

Thiotepa can irritate the bladder. You may pass urine more often, have pain when you pass urine or need to pass urine at night. If severe, your doctor may decrease or delay your next treatment.
Thiotepa can irritate your skin. This can occur if your urine comes in contact with your skin especially in the first 8 hours after your treatment. To help prevent skin problems especially in the first 8 hours afteryour treatment:

  • Wash your hands and genitals well with soap and warm water after passing urine.
  • Wash any skin that comes in contact with your urine.
  • Change any clothing that comes in contact with your urine

See your doctor or get emergency help immediately if you have:

  • Signs of an infection (rare) such as fever (over 100 degrees Fahrenheit); chill; cough; sore throat; redness, pain or swelling on any area of your body; sores forming anywhere on your body.
  • Signs of bleeding problems (rare) such as black tarry stools; pinpoint red spots on skin.

Check with your doctor if any of the following continue or bother you:

  • Severe pain when you pass urine.
  • Frequent need to pass urine.
  • Blood in urine.
  • Abdominal pain.

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Comprehensive Urologic Care in a Local Setting